UK 122 (trifluoroacetate salt)

UK 122 is an inhibitor of urokinase-type plasminogen activator (uPA, IC50 = 0.2 µM). It is selective for uPA over tissue-type plasminogen activator (tPA), trypsin, plasmin, and thrombin (IC50s = >100 µM for all). UK 122 (100 µM) inhibits the migration and invasion of CFPAC-1 pancreatic cancer cells. It prevents glutamate-induced phase shifts in isolated suprachiasmatic nucleus slices from tPA-/- but not wild-type mice when used at a concentration of 0.2 µM. UK 122 (4 mg/kg) decreases disease severity and colorectal levels of RANTES in a mouse model of colitis induced by dextran sulfate (DSS, Cay-23250).Formal Name: 4-[(E)-(5-oxo-2-phenyl-4(5H)-oxazolylidene)methyl]-benzenecarboximidamide, 2,2,2-trifluoroacetate. CAS Number: 1186653-73-5. Molecular Formula: C17H13N3O2 . CF3COOH. Formula Weight: 405.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, Methanol: Soluble. SMILES: NC(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)=N.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C17H13N3O2.C2HF3O2/c18-15(19)12-8-6-11(7-9-12)10-14-17(21)22-16(20-14)13-4-2-1-3-5-13,3-2(4,5)1(6)7/h1-10H,(H3,18,19),(H,6,7)/b14-10+,. InChi Key: KVCIDYPYQWLDKP-KMZJGFRYSA-N.