TSI-13-57

An inhibitor of Mal homodimerization and TLR signaling, inhibits the secretion of TNF-alpha induced by agonists of TLR9, -7, -2, or -4 in RAW 264.7 macrophages (IC50s = 2.7, 6.03, 7.37, and 6.38 µM, respectively), reduces LPS-induced increases in TNF-alpha levels in mouse plasma at 100 and 200 mg/kg. SMILES: OC1=CC=C(N2C(C3=CC=C(O)C=C3)=CC(C4=CC=C(OCCN5CCCCC5)C=C4)=N2)C=C1. InChi Code: InChI=1S/C28H29N3O3/c32-24-10-4-22(5-11-24)28-20-27(29-31(28)23-8-12-25(33)13-9-23)21-6-14-26(15-7-21)34-19-18-30-16-2-1-3-17-30/h4-15,20,32-33H,1-3,16-19H2. InChi Key: KSIJIGHGXBEURD-UHFFFAOYSA-N