Tryptanthrin

Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively). Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro. It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.Formal Name: indolo[2,1-b]quinazoline-6,12-dione. CAS Number: 13220-57-0. Synonyms: NSC 349447. Molecular Formula: C15H8N2O2. Formula Weight: 248.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 225, 252, 279, 311, 394 nm. SMILES: O=C1N2C(C(C3=C2C=CC=C3)=O)=NC4=C1C=CC=C4. InChi Code: InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H. InChi Key: VQQVWGVXDIPORV-UHFFFAOYSA-N.