Trovirdine

A non-nucleoside reverse transcriptase inhibitor, inhibits HIV-1 wild-type RT (IC50 = 0.017 µM) and RTL100I, RTE138R, RTY181C, RTY188H (IC50s = 0.43, 0.22, 2.5, and 0.2 µM, respectively), delays p27 antigenemia and the appearance of anti-SIV antibodies in rhesus monkeys infected with transgenic SIV expressing HIV-1 RT at 5 mg/kg, active against T. gondii (IC50 = 18.89 µM). Formulation: A solid. InChI: InChI=1S/C13H13BrN4S/c14-10-4-5-12(17-9-10)18-13(19)16-8-6-11-3-1-2-7-15-11/h1-5,7,9H,6,8H2,(H2,16,17,18,19). InChIKey: HOCFDYZWQYGULA-UHFFFAOYSA-N. SMILES: BrC(C=C1)=CN=C1NC(NCCC2=NC=CC=C2)=S