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Zu "K24802" wurden 10 Artikel gefunden!
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Artikelnummer: Cay37668-1
Festinavir is a nucleoside reverse transcriptase inhibitor (NRTI). It inhibits viral replication in HEK293 cells infected with HIV-1 expressing wild-type or M184V mutant reverse transcriptase (EC50s = 0.323 and 2.3 µM, respectively).Formal Name: 2',3'-didehydro-3'-deoxy-4'-ethynyl-thymidine. CAS Number: 634907-30-5....
Schlagworte: | 4'-Ed4T, BMS 986001, 2',3'-didehydro-3'-deoxy-4'-ethynyl-thymidine |
Anwendung: | NRTI (nucleoside reverse transcriptase inhibitor ) |
CAS | 634907-30-5 |
MW: | 248.2 D |
ab 62,00 €
Artikelnummer: Cay37669-10
Azvudine is a nucleoside reverse transcriptase inhibitor (NRTI). It reduces viral infectivity in HIV-1-infected HEK293T cells (EC50 = 0.063 nM) and reduces viral replication in 2209-23 cells stably transfected with hepatitis C virus (HCV) genotype 1b (EC50 = 24 nM). In vivo, azvudine (0.7 mg/kg) reduces viral load...
Schlagworte: | FNC, Ro0622, 4-amino-1-(4-C-azido-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone |
Anwendung: | NRTI (nucleoside reverse transcriptase inhibitor ) |
CAS | 1011529-10-4 |
MW: | 286.2 D |
ab 204,00 €
Artikelnummer: Cay36925-1
Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3'-azido-3'-deoxythymidine (zidovudine, Cay-15492) or 2',3'-dideoxyinosine (didanosine, Cay-23715),...
Schlagworte: | 1592U89, (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol |
Anwendung: | Nucleoside analog, HIV-1 reverse transcriptase inhibitor |
CAS | 136470-78-5 |
MW: | 286.3 D |
ab 96,00 €
Artikelnummer: AG-CR1-3750-M005
Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that inhibits growth of wild-type HIV with an EC50 value of 0.51nM. It is active against NNRTI-resistant HIV strains with EC50 values less than 1nM for L100I, K103N, V106A, G190A and G190S mutants in vitro. Rilpivirine also reduces growth of...
Schlagworte: | R278474, TMC278, DB08865 |
Anwendung: | Antiviral, Reverse transcriptase inhibitor |
CAS | 500287-72-9 |
MW: | 366.4 D |
ab 55,00 €
Artikelnummer: AG-CR1-3751-M010
Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs (Ki= 2.93nM and 3.85-56.5nM, respectively). It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells (IC95s =...
Schlagworte: | DMP 266, EFV, L-743,726 |
Anwendung: | Antiviral, Reverse transcriptase inhibitor |
CAS | 154598-52-4 |
MW: | 315.7 D |
ab 44,00 €
Artikelnummer: Cay36124-10
Ro 0335 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and an active metabolite of the antiviral prodrug elsulfavirine. It inhibits HIV-1 reverse transcriptase in a cell-free assay and the replication of HIV-1 in MT-4 cells (IC50s = 8.1 and 1.1 nM, respectively). Ro 0335 also selectively inhibits human...
Schlagworte: | VM 1500A, N-[4-(aminosulfonyl)-2-chlorophenyl]-4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluoro-benzeneacetamide |
Anwendung: | Elsulfavirine active metabolite, Non-nucleoside reverse transcriptase inhibitor (NNRTI) |
CAS | 867365-76-2 |
MW: | 573.2 D |
ab 109,00 €
Artikelnummer: Cay38373-2.4
2',3'-Dideoxyadenosine-5'-O-triphosphate is a reverse transcriptase inhibitor (Kis = 20 and 37 nM for the HIV and visna virus enzymes, respectively) and an active metabolite of 2',3'-dideoxyadenosine (ddA, Cay-36662) and didanosine (ddI, Cay-23715). It is formed from ddI via a 2',3'-dideoxyAMP intermediate by...
Schlagworte: | ddATP, Dideoxyadenosine-5'-triphosphate, 2',3'-dideoxy-adenosine 5'-(tetrahydrogen triphosphate), tetrasodium salt |
Anwendung: | Reverse transcriptase inhibitor |
CAS | 99827-72-2 |
MW: | 563.1 D |
272,00 €
Artikelnummer: Cay38374-2.3
2',3'-Dideoxycytidine-5'-O-triphosphate is an active metabolite of the reverse transcriptase inhibitor zalcitabine (Cay-16019). It is an inhibitor of DNA polymerases beta and gamma (Kis = 1.32 and 0.034 µM, respectively, for the human enzymes). 2',3'-Dideoxycytidine-5'-O-triphosphate (1 mM) inhibits HIV-1...
Schlagworte: | ddCTP, Dideoxycytidine 5'-triphosphate, Zalcitabine 5'-triphosphate, 2',3'-dideoxy-cytidine 5'-(tetrahydrogen... |
Anwendung: | Zalcitabine active metabolite |
MW: | 539.1 D |
218,00 €
Artikelnummer: Cay38375-2.5
2',3'-Dideoxyguanosine-5'-O-triphosphate (ddGTP) is a reverse transcriptase inhibitor (Kis = 13 and 6.7 nM for the visna virus and HIV-1 enzymes, respectively). ddGTP has been used in the synthesis of oligonucleotides containing a terminal ddG that are resistant to cleavage by severe acute respiratory syndrome...
Schlagworte: | ddGTP, 2',3'-dideoxy-guanosine 5'-(tetrahydrogen triphosphate), tetrasodium salt |
Anwendung: | Reverse transcriptase inhibitor |
MW: | 579.1 D |
543,00 €
Artikelnummer: Cay38376-2.3
2',3'-Dideoxythymidine-5'-O-triphosphate (ddTTP) is a reverse transcriptase inhibitor (Kis = 40 and 25 nM for the visna virus and HIV-1 enzymes, respectively). It also inhibits DNA polymerase gamma (Ki = 400 nM for the bovine enzyme). ddTTP has been used to terminate chain extension produced by the Taq polymerase in...
Schlagworte: | ddTTP, ((2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl triphosphate |
Anwendung: | Reverse transcriptase inhibitor |
MW: | 554.1 D |
226,00 €