Triparanol

Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 µM), which is an enzyme involved in the biosynthesis of cholesterol. It has antitumor properties, such as decreasing proliferation and inducing apoptosis in many cancer cell lines and slowing tumor growth in a mouse xenograft model. It can also decrease Hedgehog pathway signaling in cancer cells. Formulations containing triparanol were discontinued in the 1960s due to serious adverse side effects, including rapid cataract development.Formal Name: 4-chloro-alpha-[4-[2-(diethylamino)ethoxy]phenyl]-alpha-(4-methylphenyl)-benzeneethanol. CAS Number: 78-41-1. Synonyms: MER-29, NSC 65345. Molecular Formula: C27H32ClNO2. Formula Weight: 438.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.125 mg/ml. lambdamax: 224, 274 nm. SMILES: CC1=CC=C(C(CC2=CC=C(Cl)C=C2)(O)C3=CC=C(OCCN(CC)CC)C=C3)C=C1. InChi Code: InChI=1S/C27H32ClNO2/c1-4-29(5-2)18-19-31-26-16-12-24(13-17-26)27(30,23-10-6-21(3)7-11-23)20-22-8-14-25(28)15-9-22/h6-17,30H,4-5,18-20H2,1-3H3. InChi Key: SYHDSBBKRLVLFF-UHFFFAOYSA-N.