trifarotene

Description: Trifarotene (CD5789) is a potent and selective RARgamma agonist, exhibiting 65-fold and 16-fold selectivity for RARgamma (EC50=7.7 nM) over RARalpha (EC50=500 nM) and RARbeta (EC50=125 nM). Target: Autophagy, Retinoid Receptor. Smiles: CC(C)(C)c1cc(ccc1N1CCCC1)-c1cc(ccc1OCCO)-c1ccc(cc1)C(O)=O. References: J Aubert, et al. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-gamma agonist trifarotene. Br J Dermatol. 2018 Aug,179(2):442-456.