Triclabendazole

Triclabendazole is a benzimidazole anthelmintic. It eliminates both immature and adult flukes in a sheep model of F. hepatica infection when administered at a dose of 10 mg/kg. Triclabendazole (5 µM) also protects against glucose- or alpha-synuclein-induced apoptosis in S. cerevisiae via inhibition of adenylyl cyclase in the Ras-adenylyl cyclase-protein kinase A (PKA) nutrient sensing pathway.Formal Name: 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole. CAS Number: 68786-66-3. Synonyms: TCBZ. Molecular Formula: C14H9Cl3N2OS. Formula Weight: 359.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10mM. lambdamax: 222, 254, 306 nm. SMILES: ClC1=CC=CC(OC2=C(Cl)C=C(NC(SC)=N3)C3=C2)=C1Cl. InChi Code: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19). InChi Key: NQPDXQQQCQDHHW-UHFFFAOYSA-N.