TRAP-6 Peptide (trifluoroacetate salt)

TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1). It acts as an agonist of PAR1, inducing platelet aggregation in human platelet-rich plasma ex vivo (EC50 = 0.8 µM). TRAP-6 (0.3 and 0.6 mg/kg) has a triphasic effect on mean arterial blood pressure (MAP) in anesthetized rats with a short decrease, an increase, and then a longer decrease in MAP following intravenous administration.Formal Name: L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparagine, trifluoroacetate salt. Synonyms: Ser-Phe-Leu-Leu-Arg-Asn, Thrombin Receptor Agonist Peptide-6. Molecular Formula: C34H56N10O9 . XCF3COOH. Formula Weight: 748.9. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)[C@@H](NC([C@H](CO)N)=O)CC1=CC=CC=C1.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C34H56N10O9.C2HF3O2/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20,3-2(4,5)1(6)7/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39),(H,6,7)/t21-,22-,23-,24-,25-,26-,/m0./s1. InChi Key: MYWDHZOZDWFXCS-POCCEKOUSA-N.