Zu "K03914" wurden 56 Artikel gefunden!
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TRAP-6 Peptide (trifluoroacetate salt)
Artikelnummer: Cay24125-5
TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1). It acts as an agonist of PAR1, inducing platelet aggregation in human platelet-rich plasma ex vivo (EC50 = 0.8 µM). TRAP-6 (0.3 and 0.6 mg/kg) has a triphasic effect on mean arterial blood pressure (MAP) in...
| Schlagworte: | Ser-Phe-Leu-Leu-Arg-Asn, Thrombin Receptor-Agonist Peptide-6,... |
| Anwendung: | PAR1 agonist |
| MW: | 748.9 D |
173,00 €
Vorapaxar
Artikelnummer: Cay23119-1
Vorapaxar is an orally bioavailable competitive antagonist of the proteinase-activated receptor (PAR1, Ki = 8.1 nM), also known as the thrombin receptor. It is selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors. It inhibits platelet aggregation induced by thrombin...
| Schlagworte: | N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]fu... |
| Anwendung: | PAR1 competitive antagonist |
| CAS | 618385-01-6 |
| MW: | 492.6 D |
ab 85,00 €
TFLLR-NH2 (trifluoroacetate salt)
Artikelnummer: Cay27548-1
TFLLR-NH2 is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that induces calcium mobilization in isolated rat dorsal root ganglion neurons (EC50 = 1.9 µM). In vivo, TFLLR-NH2 (3 µmol/kg) stimulates plasma extravasation in the bladder, esophagus, stomach, intestine, and pancreas in wild-type,...
| Schlagworte: | (S)-2-((S)-2-((2S,3R)-2-amino-3-hydroxybutanamido)-3-phenylpropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-y... |
| Anwendung: | PAR1 agonist |
| MW: | 647.8 D |
ab 49,00 €
Vorapaxar sulfate
Artikelnummer: TGM-T3098-1mg
Description: Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist. Target: Protease-activated Receptor. Smiles: OS(O)(=O)=O.[H][C@@]12C[C@]3([H])C[C@@H](CC[C@@]3([H])[C@H](\C=C\c3ccc(cn3)-c3cccc(F)c3)[C@]1([H])[C@@H](C)OC2=O)NC(=O)OCC. References: Chackalamannil S, et al....
| Schlagworte: | Zontivity, SCH 530348 sulfate, vorapaxar monosulfate |
| Anwendung: | Targets coagulation factor II (thrombin) receptor (F2R, PAR1) |
| CAS | 705260-08-8 |
| MW: | 590.66 D |
ab 31,00 €
Anti-F2R / PAR1, Internal (near N-term)
Artikelnummer: ARG64922.100
Protein function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. [The UniProt Consortium]
| Schlagworte: | Anti-F2R, Anti-CF2R, Anti-PAR-1, Anti-Thrombin receptor, Anti-Coagulation factor II receptor, Anti-Proteinase-activated... |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
871,00 €
Human PAR-1 / Proteinase-activated receptor 1 ELISA Kit
Artikelnummer: G-HUFI00814.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Mouse PAR-1 / Proteinase-activated receptor 1 ELISA Kit
Artikelnummer: G-MOFI00295.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
698,00 €
Anti-PAR1 / F2R / Thrombin Receptor
Artikelnummer: NSJ-R32032
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Proteinase-activated receptor 1 (PAR-1), also known as the coagulation factor II (thrombin) receptor, is a protein that in humans is encoded by the F2R gene. By fluorescence in situ hybridization, this gene is mapped to 5q13, confirming its presence as a single...
| Schlagworte: | Anti-F2R, Anti-CF2R, Anti-PAR-1, Anti-Thrombin receptor, Anti-Coagulation factor II receptor, Anti-Proteinase-activated... |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
790,00 €
Anti-PAR1
Artikelnummer: NSJ-R36263-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Protease-activated receptor 1 antibody, thrombin receptor, TR, F2R, coagulation factor II (thrombin) receptor Protein function: High affinity receptor for activated thrombin coupled to G...
| Schlagworte: | Anti-F2R, Anti-CF2R, Anti-PAR-1, Anti-Thrombin receptor, Anti-Coagulation factor II receptor, Anti-Proteinase-activated... |
| Anwendung: | WB, IHC (paraffin), ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
ML161
Artikelnummer: BPS-27764-1
Allosteric and reversible inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 µM for the inhibition of platelet P-selectin expression on human platelets).
| Schlagworte: | 2-bromo-N-[3-(butanoylamino)phenyl]benzamide, |
| Anwendung: | PAR1 inhibitor |
| MW: | 361.2 D |
ab 378,00 €
SCH 79797 (hydrochloride)
Artikelnummer: Cay14633-10
SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1). It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or alpha-thrombin (IC50 = 0.3 and 3 µM, respectively). SCH 79797 has no...
| Schlagworte: | N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine, monohydrochloride |
| Anwendung: | PAR1 antagonist |
| CAS | 1216720-69-2 |
| MW: | 444.4 D |
ab 68,00 €
Anti-F2R / PAR1
Artikelnummer: ARG58165.100
Protein function: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. [The UniProt Consortium]
| Schlagworte: | Anti-F2R, Anti-CF2R, Anti-PAR-1, Anti-Thrombin receptor, Anti-Coagulation factor II receptor, Anti-Proteinase-activated... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
707,00 €