(±)-trans-ACPD

(±)-trans-ACPD is an agonist of metabotropic glutamate receptors (mGluRs, EC50s = 15, 2, 40, 23, and 82 µM for mGluR1, -2, -3, -5, and -6, respectively, in CHO cells expressing recombinant receptors). It also activates mGluR4 in baby hamster kidney cells with an EC50 value of approximately 800 µM. (±)-trans-ACPD increases cAMP accumulation in adult rat cerebral cortex slices (EC50 = 47.8 µM) but not in isolated rat embryonic neurons or neonatal glial cells when used at concentrations ranging from 1 to 1,000 µM. (±)-trans-ACPD (10-1,000 µM) increases phosphoinositide hydrolysis in neonatal rat cerebral cortex and hippocampal slices. It induces clonic convulsions in neonatal rats (ED50 = 100 mg/kg), an effect that can be reversed by administration of the NMDA receptor antagonists LY233053 and LY274614.Formal Name: (1R,3S)-1-aminocyclopentane-1,3-dicarboxylic acid. CAS Number: 67684-64-4. Molecular Formula: C7H11NO4. Formula Weight: 173.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Water: slightly soluble. SMILES: OC([C@H]1CC[C@@](C(O)=O)(N)C1)=O. InChi Code: InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m0/s1. InChi Key: YFYNOWXBIBKGHB-MHTLYPKNSA-N.