Tpl2 Kinase Inhibitor

Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2, IC50 = 0.05 µM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-alpha production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 µM, respectively). It enhances differentiation induced by 1,25-dihydroxy vitamin D3 (calcitriol, Cay-71820) in HL-60 and U937 leukemia cells when used at a concentration of 5 µM. Tpl2 kinase inhibitor (5 µM) inhibits the proliferation of KG-1a leukemia cells.Formal Name: 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile. CAS Number: 871307-18-5. Synonyms: c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor. Molecular Formula: C21H14ClFN6. Formula Weight: 404.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS(pH7.2) (1:2): 0.33 mg/ml, DMSO: 1 mg/ml. lambdamax: 251, 293, 315, 417 nm. SMILES: FC(C=C1)=C(Cl)C=C1NC2=C(C#N)C=NC(C=N3)=C2C=C3NCC4=CN=CC=C4. InChi Code: InChI=1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28). InChi Key: NMEUKWOOQOHUNA-UHFFFAOYSA-N.