Zu "K04415" wurden 48 Artikel gefunden!
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Cot Inhibitor 1
Artikelnummer: Cay43368-1
Cot inhibitor 1 is an inhibitor of MAP3K8 (IC50 = 28 nM). It inhibits LPS-induced increases in TNF-alpha levels in isolated human whole blood (IC50 = 5. µM).. Solulibility: DMSO: Soluble: = 10 mg/ml: .
| Schlagworte: | 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]... |
| Anwendung: | MAP3K8 (COT) inhibitor |
| CAS | 915365-57-0 |
| MW: | 553.47 D |
ab 96,00 €
Tpl2 Kinase Inhibitor
Artikelnummer: Cay19710-1
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2, IC50 = 0.05 µM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-alpha production in isolated human monocytes and whole...
| Schlagworte: | c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor,... |
| Anwendung: | c-Cot (MAP3K8) inhibitor |
| CAS | 871307-18-5 |
| MW: | 404.8 D |
ab 85,00 €
Tpl2 Kinase Inhibitor (hydrochloride)
Artikelnummer: Cay34059-1
Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2, IC50 = 0.05 µM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 µM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-alpha production in isolated human monocytes and whole...
| Schlagworte: | c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor,... |
| Anwendung: | MAP3K8/COT/Tpl2 inhibitor |
| MW: | 404.8 D |
ab 85,00 €
Cot (MAP3K8), GST-His-tags
Artikelnummer: BPS-40050
Human Cot/Tpl2 (GenBank Accession No. NM_005204), (a.a. 30-397), with N-terminal GST-His-tag, MW= 72 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
| Schlagworte: | COT, TPL-2, MAP3K8, EC=2.7.11.25, Proto-oncogene c-Cot, Tumor progression locus 2, Cancer Osaka thyroid oncogene,... |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 72 kD |
536,00 €
Cot/Tpl2, mouse recombinant protein
Artikelnummer: BPS-41050
Mouse, recombinant, N-terminal His-GST-tag Description: Mouse Cot kinase (MAP3K8) GenBank Accession No. NM_007746, a.a. 30-397, with N-terminal His-GST-tag, expressed in a Baculovirus infected Sf9 cell expression system. The theoretical MW is 70 kDa. Specific Activity: 8.5 pmole/min/mg
| Schlagworte: | Cot, TPL-2, Map3k8, EC=2.7.11.25, Proto-oncogene c-Cot, Tumor progression locus 2, Cancer Osaka thyroid oncogene,... |
| Anwendung: | Enzyme kinetics |
| Exprimiert in: | Baculovirus |
| Ursprungsart: | mouse |
| MW: | 70 kD |
536,00 €
Anti-MAP3K8
Artikelnummer: ARG58418.100
Protein function: Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG...
| Schlagworte: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
707,00 €
Anti-MAP3K8
Artikelnummer: ARG58432.50
Protein function: Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG...
| Schlagworte: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
| Anwendung: | IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
551,00 €
Anti-MAP3K8
Artikelnummer: ATA-HPA017962.100
Protein function: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression...
| Schlagworte: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-MAP3K8
Artikelnummer: CSB-PA001760.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-MAP3K8
Artikelnummer: CSB-PA007158.50
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-COT, Anti-TPL-2, Anti-MAP3K8, EC=2.7.11.25, Anti-Proto-oncogene c-Cot, Anti-Tumor progression locus 2, Anti-Cancer... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
126,00 €
Anti-Phospho-MAP3K8 (T290)
Artikelnummer: CSB-PA000735.100
Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...
| Schlagworte: | Anti-phospho-COT, Anti-phospho-TPL-2, Anti-phospho-MAP3K8, EC=2.7.11.25, Anti-phospho-Proto-oncogene c-Cot,... |
| Anwendung: | ELISA, WB, IHC, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 126,00 €
Anti-Phospho-MAP3K8 (Ser400)
Artikelnummer: CSB-PA588716.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: Antibodies were produced by immunizing rabbits with...
| Schlagworte: | Anti-phospho-COT, Anti-phospho-TPL-2, Anti-phospho-MAP3K8, EC=2.7.11.25, Anti-phospho-Proto-oncogene c-Cot,... |
| Anwendung: | ELISA, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
340,00 €