TP-021

TP-021 is an inhibitor of the protein-protein interaction between Bcl-6 and Bcl-6 corepressor (BCoR). It inhibits the protein-protein interaction between the Bcl-6 BTB domain and BCoR in a mammalian two-hybrid assay (IC50 = 0.72 µM).Formal Name: 6-[[2-chloro-4-nitro-5-[(tetrahydro-2H-pyran-4-yl)oxy]phenyl]amino]-3,4-dihydro-2(1H)-quinolinone. CAS Number: 2130878-25-8. Molecular Formula: C20H20ClN3O5. Formula Weight: 417.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml, DMSO: Sparingly Soluble: 1-10 mg/ml. SMILES: ClC1=C(NC2=CC=C(N3)C(CCC3=O)=C2)C=C(OC4CCOCC4)C([N+]([O-])=O)=C1. InChi Code: InChI=1S/C20H20ClN3O5/c21-15-10-18(24(26)27)19(29-14-5-7-28-8-6-14)11-17(15)22-13-2-3-16-12(9-13)1-4-20(25)23-16/h2-3,9-11,14,22H,1,4-8H2,(H,23,25). InChi Key: RRELDGDKULRRDM-UHFFFAOYSA-N.