TNP

TNP is a cell-permeable inhibitor of inositol-1,4,5-trisphosphate 6-kinase 1 (IP6K1, IC50 = 0.55 µM, Ki = 0.24 µM) and IP3K (IC50 = 10.2 µM, Ki = 4.3 µM) that binds to the ATP-binding sites of both enzymes. TNP reduces IP7 and IP8 levels (IC50s = ~3 and 1 µM, respectively) and inhibits insulin release in MIN6 cells. It increases intracellular calcium levels in a concentration-dependent manner in HL-60 cells, potentially due to a 2- to 3-fold accumulation of IP3, and induces degranulation in mast cells.Formal Name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-purine-2,6-diamine. CAS Number: 519178-28-0. Synonyms: IP3K Inhibitor, IP6K Inhibitor. Molecular Formula: C20H16F3N7O2. Formula Weight: 443.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 2 mg/ml. lambdamax: 227, 260, 289 nm. SMILES: FC(C1=CC=CC(CNC2=NC(N=CN3)=C3C(NCC4=CC=C([N+]([O-])=O)C=C4)=N2)=C1)(F)F. InChi Code: InChI=1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29). InChi Key: DDSBPUYZPWNNGH-UHFFFAOYSA-N.