TMCB

TMCB is a dual inhibitor of casein kinase 2 (CK2) and ERK8 (IC50 = 0.5 µM for both). It also binds to Pim-1, HIPK2, and DYRK1A (Kis = 8.65, 15.25, and 11.9 µM, respectively) and inhibits greater than 50% of the activity of five kinases, including CK2, ERK8, and DYRK2, in a panel of 78 kinases at 10 µM. TMCB induces apoptosis in Jurkat cells when used at concentrations ranging from 10 to 50 µM.Formal Name: 4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazole-1-acetic acid. CAS Number: 1085822-09-8. Molecular Formula: C11H9Br4N3O2. Formula Weight: 534.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mM. lambdamax: 240, 274 nm. SMILES: BrC1=C(Br)C(Br)=C(Br)C2=C1N=C(N(C)C)N2CC(O)=O. InChi Code: InChI=1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20). InChi Key: PHAOTASRLQMKBE-UHFFFAOYSA-N.