TL4-12

TL4-12 is an inhibitor of MAP4K2 (IC50 = 37. nM). It is selective for MAP4K2 over 20 other kinases at 1 µM. TL4-12 (500 nM) inhibits IL-1alpha- or TGF-beta-induced increases in p38 phosphorylation in primary mouse embryonic fibroblasts. It induces apoptosis in MM.1S multiple myeloma cells when used at concentrations of 1 or 3 µM.. Solulibility: DMSO: Slightly soluble: 0.1-1 mg/ml: .