Tiotropium (bromide)

Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors). It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).Formal Name: (1alpha,2beta,4beta,5alpha,7beta)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide. CAS Number: 136310-93-5. Synonyms: BA 679BR. Molecular Formula: C19H22NO4S2 . Br. Formula Weight: 472.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 238 nm. SMILES: O=C(C(C1=CC=CS1)(O)C2=CC=CS2)O[C@H]3C[C@H]4[C@H]5[C@H](O5)[C@H]([N+]4(C)C)C3.[Br-]. InChi Code: InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15,/h3-8,11-13,16-17,22H,9-10H2,1-2H3,1H/q+1,/p-1/t11-,12-,13+,16-,17+,. InChi Key: DQHNAVOVODVIMG-FOGIBKMMSA-M.