Tilmicosin (phosphate)

Tilmicosin is a macrolide antibiotic. It is active against macrolide-susceptible strains of M. haemolytica, P. multocida, and E. coli (MICs = 4, 4, and 128 µM, respectively), as well as a hyperpermeable strain of E. coli (MIC = 2 µM), and inhibits bacterial protein synthesis (IC50 = 0.36 µM). Tilmicosin (75 mg/kg) increases serum creatine kinase (CK), the MB isoform of CK (CK-MB), and malondialdehyde (MDA) levels in mice, indicating cardiotoxicity. Formulations containing tilmicosin have been used in the treatment of respiratory diseases in sheep and cattle.Formal Name: 4A-O-de(2,6-dideoxy-3-C-methyl-alpha-L-ribo-hexopyranosyl)-20-deoxo-20-[(3R,5S)-3,5-dimethyl-1-piperidinyl]-tylosin, monophosphate. CAS Number: 137330-13-3. Synonyms: EL-870, LY-177370. Molecular Formula: C46H80N2O13 . H3PO4. Formula Weight: 967.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 290 nm. SMILES: CC[C@@H](OC(C[C@@H](O)[C@H](C)[C@@H](O[C@@]1([H])[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H](C)O1)[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)C[C@H]3C)=O)[C@@H](CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C=C(C)/C=C/C3=O.O=P(O)(O)O. InChi Code: InChI=1S/C46H80N2O13.H3O4P/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45,1-5(2,3)4/h14-15,19,26-33,35-36,38-4. InChi Key: NESIVXZOSKKUDP-ARVJLQODSA-N.