TG53

TG53 is an inhibitor of the protein-protein interaction between transglutaminase 2 (TG2) and fibronectin (IC50 = 10 µM in a cell-free assay). It inhibits the adhesion of SKOV3 ovarian cancer cells to fibronectin-coated wells when used at a concentration of 25 µM. TG53 (10 µM) inhibits migration and invasion in a scratch assay using SKOV3 cells.. Solulibility: DMSO: Soluble: =10 mg/ml: Ethanol: Slightly soluble: 0.1-1 mg/ml.