Terreic Acid

Terreic acid (TA) is a cell-permeable quinone epoxide that selectively inhibits Bruton's tyrosine kinase (BTK) catalytic activity (IC50s = 10 and 3 µM for basal and activation levels, respectively). TA binds to the BTK pleckstrin homology domain (BTK-PH) and blocks the interaction between BTK-PH and PKC (IC50 = 100 µM in human mast cell lysates) without affecting the activity of PKC. TA has minimal effect on Lyn, Syk, PKA, casein kinase I, ERK1, ERK2, and p38 kinase activities.Formal Name: (1R,6S)-3-hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione. CAS Number: 121-40-4. Synonyms: TA, (-)-Terreic Acid. Molecular Formula: C7H6O4. Formula Weight: 154.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: 10 mg/ml, Ethanol: soluble, Methanol: soluble, Water: 5 mg/ml. SMILES: O=C(C(O)=C1C)[C@H]2[C@H](O2)C1=O. InChi Code: InChI=1S/C7H6O4/c1-2-3(8)5(10)7-6(11-7)4(2)9/h6-8H,1H3/t6-,7+/m1/s1. InChi Key: ATFNSNUJZOYXFC-RQJHMYQMSA-N.