TCS 401

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B, Ki = 0.29 µM). It inhibits the protein phosphatases CD45 D1D2, PTPbeta, PTPepsilon D1, SHP-1, PTPalpha D1, and LAR D1D2 at much higher concentrations (Kis = 59, 560, 1,100, >2,000, >2,000, and >2,000 µM, respectively). Several PTPs have been proposed to act as negative regulators of insulin signaling, thus this enzyme is a potential drug target in diabetes.Formal Name: 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid, monohydrochloride. CAS Number: 243966-09-8. Molecular Formula: C10H10N2O5S . HCl. Formula Weight: 306.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1 M NaOH: 5 mg/ml. SMILES: OC(C1=C(NC(C(O)=O)=O)SC2=C1CCNC2)=O.Cl. InChi Code: InChI=1S/C10H10N2O5S.ClH/c13-7(10(16)17)12-8-6(9(14)15)4-1-2-11-3-5(4)18-8,/h11H,1-3H2,(H,12,13)(H,14,15)(H,16,17),1H. InChi Key: LQGCAMWQDSYOAY-UHFFFAOYSA-N.