Zu "K05696" wurden 90 Artikel gefunden!
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Anti-Recombinant Phospho-PTP1B (Ser386), clone A346
Artikelnummer: E-AN301643L.100
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK, inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the...
| Schlagworte: | Anti-PTPN1, Anti-Protein-tyrosine phosphatase 1B, Anti-Tyrosine-protein phosphatase non-receptor type 1, Recombinant... |
| Anwendung: | WB, IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 304,00 €
KY-226
Artikelnummer: Cay43555-10
KY-266 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B, IC50 = 0. µM). It enhances insulin-induced phosphorylation of insulin receptors in HepG2 cells when used at concentrations of 1, 3, and 10 µM. In vivo, KY-266 (10 and 30 mg/kg) reduces plasma glucose and triglyceride levels and hemoglobin A1c (HbA1c)...
| Schlagworte: | 4-[[([1,1'-biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)-benzamide |
| Anwendung: | PTP1B inhibitor |
| CAS | 1621673-53-7 |
| MW: | 481.67 D |
ab 88,00 €
CX-08005
Artikelnummer: Cay42730-1
CX-08005 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B, IC50 = 0. µM). It is selective for PTP1B over Src homology region 2 domain-containing phosphatase 1 (SHP-1), dual-specificity phosphatase 3 (DUSP3), and leukocyte common antigen-related (LAR) phosphatase at 10 µM but does inhibit T cell protein...
| Schlagworte: | 2-[[[2-(tetradecyloxy)phenyl]amino]carbonyl]-benzoic acid |
| Anwendung: | PTP1B inhibitor |
| CAS | 1256341-22-6 |
| MW: | 453.62 D |
ab 42,00 €
PTP1B (human, recombinant)
Artikelnummer: Cay10010896-100
Protein tyrosine phosphatase (PTPs) are an enzyme superfamily that includes about 100 human proteins. Their function is to remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is of paramount...
| Schlagworte: | PTPN1, PTP1B, PTP-1B, PTP-1B, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase 1B, Tyrosine-protein... |
| Anwendung: | Enzyme activity |
| MW: | 37,3 kD |
409,00 €
PTP1B full length, active human recombinant protein
Artikelnummer: BPS-30009
Active protein tyrosine phosphatase, full length, (a.a. 1-436), (Gene bank accession number M31724) with N terminal GST tag, MW=76 kDa, expressed in an E. coli expression system.
| Schlagworte: | PTP1B, PTPN1, PTP-1B, EC=3.1.3.48, Protein-tyrosine phosphatase 1B, Tyrosine-protein phosphatase non-receptor type 1, |
| Anwendung: | Enzyme kinetics, dephosphorylation, inhibitor screening |
| MW: | 76 kD |
491,00 €
3,8'-Biapigenin
Artikelnummer: Cay34143-1
3,8'-Biapigenin is a polyketide synthase-derived biflavonoid that has been found in Hypericum and has diverse biological activities. It inhibits protein tyrosine phosphatase 1B (PTP1B, IC50 = 4.5 µM) and stimulates glucose uptake in 3T3-L1 adipocyte cells when used at concentrations of 5 and 10 µM. 3,8'-Biapigenin...
| Schlagworte: | 3,8"-Biapigenin, I3,II8-Biapigenin, 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-[3,8'-bi-4H-1-benzopyran]-4,4'-dione |
| Anwendung: | Bioactive biflavonoid, PTP1B inhibitor |
| CAS | 101140-06-1 |
| MW: | 538.5 D |
ab 93,00 €
Bakuchiol
Artikelnummer: Cay11684-10
Bakuchiol is a natural meroterpene isolated from P. corylifolia, a plant used in traditional Asian medicine. In addition to having antioxidant and antibacterial actions, bakuchiol has retinol-like effects on gene expression and properties of the skin. Bakuchiol also inhibits DNA polymerase and...
| Schlagworte: | (S)-(+)-Bakuchiol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]-phenol |
| Anwendung: | PTP1B inhibitor |
| CAS | 10309-37-2 |
| MW: | 256.4 D |
ab 80,00 €
PTP1B Inhibitor
Artikelnummer: Cay15782-1
Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer. PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively). It binds reversibly and non-competitively, altering the...
| Schlagworte: | Protein Tyrosine Phosphatase 1B Inhibitor,... |
| Anwendung: | Cell-permeable allosteric PTP1B inhibitor |
| CAS | 765317-72-4 |
| MW: | 741.5 D |
ab 92,00 €
Fluorogenic PTP1B (Catalytic Region) Assay Kit
Artikelnummer: BPS-79764
Protein phosphorylation is one of the most important post-translational modification processes. Phosphorylation is reversibly regulated by Protein Kinases (PKs) and Protein Phosphatases (PTPs). PTP1B (PTPN1) is known to catalyze dephosphorylation of insulin receptor kinases and plays a critical role in insulin...
| Schlagworte: | PTPN1, Protein tyrosine phosphatase 1B, ptp, |
| Anwendung: | Enzyme kinetics, HTS |
| Spezies-Reaktivität: | human |
670,00 €
PTP1B(1-321)/PTPN1, active human recombinant protein
Artikelnummer: BPS-30010
Active protein tyrosine phosphatase, recombinant from E.coli, catalytic domain, (a.a. 1-321), (Gene bank accession no. M31724) with N-terminal GST tag, MW=63.3 kDa, expressed in an E. coli expression system.
| Schlagworte: | PTP1B, PTPN1, PTP-1B, EC=3.1.3.48, Protein-tyrosine phosphatase 1B, Tyrosine-protein phosphatase non-receptor type 1, |
| Anwendung: | Enzyme kinetics, dephosphorylation, inhibitor screening |
| MW: | 63.3 kD |
491,00 €
RK-682 (calcium salt)
Artikelnummer: Cay19450-500
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation,...
| Schlagworte: | CI-010, TAN 1364B, (5R)-4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-2(5H)-furanone, calcium salt (2:1) |
| Anwendung: | Protein tyrosine phosphatase inhibitor |
| CAS | 332131-32-5 |
| MW: | 775.1 D |
ab 360,00 €
PTP Inhibitor IV
Artikelnummer: Cay18458-10
Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation,...
| Schlagworte: | Protein Tyrosine Phosphatase Inhibitor IV,... |
| Anwendung: | SHP-2, PTP1B, PTP-epsilon, PTP-Meg-2, PTP-sigma, PTP-beta, PTP-µ inhibitor |
| CAS | 329317-98-8 |
| MW: | 608.6 D |
ab 49,00 €