TC-G 1006

TC-G 1006 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces calcium mobilization in cells expressing S1P1 over cells expressing S1P2, S1P3, S1P4, or S1P5 (EC50s = 0. >25, >25, >50, and 4. µM, respectively). TC-G 1006 (0. 1, and 3 mg/kg) reduces the number of circulating lymphocytes in rats. Formal Name: 4-methoxy-N-[[[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]amino]carbonyl]-3-pyridinecarboxamide. CAS Number: 1324003-64-6. Molecular Formula: C21H16F3N3O3. Formula Weight: 415.4. Purity: >98%. Formulation (Request formulation change): A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(NC(C1=CN=CC=C1OC)=O)NC(C=C2C(F)(F)F)=CC=C2C3=CC=CC=C3. InChi Code: InChI=1S/C21H16F3N3O3/c1-30-18-9-10-25-12-16(18)19(28)27-20(29)26-14-7-8-15(13-5-3-2-4-6-13)17(11-14)21(22,23)24/h2-12H,1H3,(H2,26,27,28,29). InChi Key: MLDQTQOMWDNTNN-UHFFFAOYSA-N. Storage: -20°C. Stability: > 4 years.