Tanshinone IIA sulfonate sodium

Description: Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza, a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 µM) inhibits hypoxia-induced PKG and PPAR-gamma downregulation in PASMCs and distal pulmonary arteries of rats. Target: P450, CaMK, Calcium Channel. Smiles: [Na+].Cc1c2c(oc1S([O-])(=O)=O)-c1ccc3c(CCCC3(C)C)c1C(=O)C2=O. References: Xu QQ, et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016,22016:19852536.