TA-01

TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Cay-13067, Cay-13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 µM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1epsilon (CK1epsilon) and CK1Delta and reduces expression of Wnt/beta-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.Formal Name: 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-pyridine. CAS Number: 1784751-18-3. Molecular Formula: C20H12F3N3. Formula Weight: 351.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml, DMSO: 3 mg/ml. lambdamax: 289 nm. SMILES: FC1=CC=CC(F)=C1C2=NC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2. InChi Code: InChI=1S/C20H12F3N3/c21-14-6-4-12(5-7-14)18-19(13-8-10-24-11-9-13)26-20(25-18)17-15(22)2-1-3-16(17)23/h1-11H,(H,25,26). InChi Key: TWPJJJZCYVFUOA-UHFFFAOYSA-N.