Sulindac sulfide

Sulindac sulfide is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor sulindac (Item No, 10004386). It inhibits both COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively), whereas the parent compound, sulindac, is much less effective (IC50 = 58 µM for COX-2 and > 100 µM for COX-1). Sulindac sulfide also inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications. It increases the expression and activity of NAD(P)H quinone oxidoreductase 1. Sulindac sulfide inhibits colorectal cancer growth both in vitro and in vivo.Formal Name: 5-fluoro-2-methyl-1Z-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid. CAS Number: 49627-27-2. Molecular Formula: C20H17FO2S. Formula Weight: 340.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:5): .15 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 0.05 mg/ml. lambdamax: 203, 258, 341, 347 nm. SMILES: O=C(O)CC(C1=C/2C=CC(F)=C1)=C(C)C2=C/C3=CC=C(SC)C=C3. InChi Code: InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9+. InChi Key: LFWHFZJPXXOYNR-RQZCQDPDSA-N.