Sulfamethoxazole-d4

Sulfamethoxazole-d4 is intended for use as an internal standard for the quantification of sulfamethoxazole (Cay-23613) by GC- or LC-MS. Sulfamethoxazole is a sulfonamide antibiotic. It inhibits growth of E. coli (MIC = 10 µg/ml) and clinical isolates of methicillin-resistant S. aureus (MRSA, MICs = 25-50 µg/ml). Sulfamethoxazole, in combination with trimethoprim (Cay-16473) at a ratio of 20:1, inhibits growth of MRSA in vivo in mice (MIC = 0.8 µg/ml, ED50s = 6.4 and 9.6 mg/kg for two MRSA strains). In a mouse model of urinary tract infection with E. coli, a combination of sulfamethoxazole and trimethoprim decreases recurrent infection when administered for 10 days. Sulfamethoxazole acts by inhibiting dihydropteroate synthase (DHPS), which converts pteridine and 4-aminobenzoic acid (PABA, Cay-18659) to dihydropteroate, an intermediate in folate biosynthesis. It inhibits recombinant P. carinii DHPS (IC50 = 23 nM, Ki = 7.5 nM) and folate biosynthesis in situ by 48.6%. Formulations containing sulfamethoxazole and trimethoprim have been used to treat bronchitis, prostatitis, and urinary tract infections among other infectious conditions.Formal Name: 4-amino-N-(5-methyl-3-isoxazolyl)-benzene-2,3,5,6-d4-sulfonamide. CAS Number: 1020719-86-1. Molecular Formula: C10H7D4N3O3S. Formula Weight: 257.3. Purity: >99% deuterated forms (d1-d4), =1% d0. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: NC1=C([2H])C([2H])=C(S(NC2=NOC(C)=C2)(=O)=O)C([2H])=C1[2H]. InChi Code: InChI=1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)/i2D,3D,4D,5D. InChi Key: JLKIGFTWXXRPMT-QFFDRWTDSA-N.