STM2457

STM2457 is an inhibitor of the methyltransferase-like 3 (METTL3) and METTL14 complex (IC50 = 16.9 µM). It inhibits growth in a panel of acute myeloid leukemia (AML) cell lines (IC50s = 0.6-10.3 µM). STM2457 also inhibits the proliferation, migration, and invasion of HuCC-T1 and HCCC-9810 intrahepatic cholangiocarcinoma (ICC) cells in a concentration-dependent manner. It increases survival in a patient-derived xenograft (PDX) mouse model of AML when administered at a dose of 50 mg/kg.Formal Name: N-[[6-[[(cyclohexylmethyl)amino]methyl]imidazo[1,2-a]pyridin-2-yl]methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide. CAS Number: 2499663-01-1. Molecular Formula: C25H28N6O2. Formula Weight: 444.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: Slightly soluble, Ethanol: Slightly soluble. lambdamax: 225 nm. SMILES: O=C1C=C(C(NCC2=CN3C=C(CNCC4CCCCC4)C=CC3=N2)=O)N=C5C=CC=CN15. InChi Code: InChI=1S/C25H28N6O2/c32-24-12-21(29-23-8-4-5-11-31(23)24)25(33)27-15-20-17-30-16-19(9-10-22(30)28-20)14-26-13-18-6-2-1-3-7-18/h4-5,8-12,16-18,26H,1-3,6-7,13-15H2,(H,27,33). InChi Key: OBERVORNENYOLE-UHFFFAOYSA-N.