Staurosporine

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-alpha approximately 100- and 1,000-fold better than PKC-delta and PKC-zeta, respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.Formal Name: 2,3,10,11,12,13-hexahydro-10R-methoxy-9S-methyl-11R-methylamino-9S,13R-epoxy-1H,9H-diindolo[1,2,3-gh,3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one. CAS Number: 62996-74-1. Synonyms: Stsp. Molecular Formula: C28H26N4O3. Formula Weight: 466.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 500 µg/ml, Methanol: 2 mg/ml. lambdamax: 241, 295, 337, 355, 373 nm. SMILES: [H][C@]12N(C3=C(N([C@](O2)(C)[C@H](OC)[C@H](NC)C1)C4=C5C=CC=C4)C5=C(CNC6=O)C6=C37)C8=C7C=CC=C8. InChi Code: InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1. InChi Key: HKSZLNNOFSGOKW-FYTWVXJKSA-N.