SRS16-86

SRS16-86 is an inhibitor of ferroptosis. It inhibits ferroptosis induced by erastin (Cay-17754) in HT-1080 and NIH3T3 cells when used at a concentration of 1 µM. SRS16-86 (2 mg/kg) prevents renal tubular damage and increases in serum levels of urea and creatine in a mouse model of renal ischemia-reperfusion injury (IRI). In a rat model of spinal cord injury, SRS16-86 (15 mg/kg) increases the levels of glutathione peroxidase 4 (GPX4), system xc- cystine/glutamate transporter (xCT), and glutathione (GSH) and decreases levels of IL-1beta, TNF-alpha, ICAM-1, and the lipid peroxidation marker 4-hydroxy nonenal (4HNE) in injured spinal cord epicenters. It also increases tissue sparing and improves locomotor recovery in the same model.Formal Name: 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-benzoic acid, 1,1-dimethylethyl ester. CAS Number: 1793052-96-6. Molecular Formula: C26H32N4O2. Formula Weight: 432.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 25 mg/ml. lambdamax: 238, 303, 429 nm. SMILES: O=C(OC(C)(C)C)C1=CC=C(NC23C[C@H]4C[C@H](C[C@H](C4)C3)C2)C(/N=C\C5=CN=CN=C5)=C1. InChi Code: InChI=1S/C26H32N4O2/c1-25(2,3)32-24(31)21-4-5-22(23(9-21)29-15-20-13-27-16-28-14-20)30-26-10-17-6-18(11-26)8-19(7-17)12-26/h4-5,9,13-19,30H,6-8,10-12H2,1-3H3/b29-15-/t17-,18+,19-,26?. InChi Key: DFENTOUMMDWZAF-WFRXSUHXSA-N.