Solifenacin-d5 (succinate)

Solifenacin-d5 is intended for use as an internal standard for the quantification of solifenacin (Cay-17320) by GC- or LC-MS. Solifenacin is a competitive antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (Kis = 25, 125, and 10 nM, respectively, for the human receptors). It inhibits calcium mobilization induced by carbamoylcholine (carbachol, Cay-14486) in isolated guinea pig detrusor muscle cells (Ki = 4 nM). Solifenacin inhibits carbachol-induced contraction of isolated guinea pig urinary bladder smooth muscle. In vivo, solifenacin (0.03-1 mg/kg) inhibits carbachol-induced increases in urinary bladder pressure in anesthetized rats. Formulations containing solifenacin have been used in the treatment of overactive bladder.Formal Name: butanedioic acid, compd. with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-(phenyl-2,3,4,5,6-d5)-2(1H)-isoquinolinecarboxylate. Molecular Formula: C23H21D5N2O2 . C4H6O4. Formula Weight: 485.6. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble, Water: soluble. SMILES: O=C(O[C@H]1CN2CCC1CC2)N3[C@@H](C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H])C5=CC=CC=C5CC3.OC(CCC(O)=O)=O. InChi Code: InChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19,5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2,1-2H2,(H,5,6)(H,7,8)/t21-,22-,/m0./s1/i1D,2D,3D,7D,8D,. InChi Key: RXZMMZZRUPYENV-BCZWPACGSA-N.