SMBA1

A Bax activator (Ki = 43.3 nM in a fluorescence polarization assay), selectively reduces viability in wild-type but not Bax-/- MEFs at 25 µM, inhibits nicotine-induced increases in phosphorylated Bax levels in A549 cells at 5 µM, reduces viability in A549 cells at 5 µM, induces cell cycle arrest at the G2/M phase in U87MG cells at 5, 10, or 15 µM, disrupts the mitochondrial membrane potential in U87MG cells at 15 µM, induces cytochrome c release from mitochondria and Bax insertion into mitochondrial membranes in A549 cells at 5 or 10 µM, decreases tumor volume in an A549 mouse xenograft model at 40 or 60 mg/kg per day. Formulation: A solid. InChI: InChI=1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H. InChIKey: PEYKRJBXACUOOB-UHFFFAOYSA-N. SMILES: OC1=C(C=C2C3=CC=CC=C3C4=C2C=C(C=C4)[N+]([O-])=O)C=CC=C1