SLX-4090

SLX-4090 is an inhibitor of microsomal triglyceride transfer protein (MTTP, IC50 = 8 nM). It selectively inhibits MTTP-mediated secretion of apolipoprotein B (ApoB) over ApoA1 in primary human hepatocytes (IC50s = 81 and >30,000 nM, respectively). In vivo, SLX-4090 reduces postprandial increases in serum triglyceride levels in rats (ED50 = 7 mg/kg). It reduces serum triglyceride levels, weight gain, and total cholesterol levels in ApoE-/- mice fed a high-fat diet when administered at a dose of 5. mg/kg per day.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/mL: Ethanol: Slightly soluble: 0.1-1 mg/mL.