SKI2852

An 11beta-HSD1 inhibitor (IC50s = 2.9 and 1.6 nM for the human and mouse enzymes, respectively), reduces postprandial blood glucose, HbA1c, blood LDL and total cholesterol, and blood triglyceride levels in an ob/ob mouse model of type 2 diabetes and metabolic syndrome at 20 mg/kg orally. SMILES: O=C(C1=NC(N(CCN(C(C=CC([S](C)(=O)=O)=C2)=C2F)C3)[C@@H]3C)=NC=C1)N[C@@H]([C@]4([H])C5)[C@@](C[C@@H]6C4)([H])C[C@@]5(C6)O. InChi Code: InChI=1S/C27H34FN5O4S/c1-16-15-32(23-4-3-20(11-21(23)28)38(2,36)37)7-8-33(16)26-29-6-5-22(30-26)25(34)31-24-18-9-17-10-19(24)14-27(35,12-17)13-18/h3-6,11,16-19,24,35H,7-10,12-15H2,1-2H3,(H,31,34)/t16-,17-,18-,19+,24-,27-/m1/s1. InChi Key: SSKKTEYBWOVEET-MYCXXBLFSA-N