Sisunatovir

An RSV fusion inhibitor (IC50 = 0.9 nM), reduces RSV A2 replication in a plaque reduction assay in vitro (EC50 = 1.3 nM), decreases lung viral titers in a mouse model of RSV infection at 1, 10, or 50 mg/kg. Formulation: A solid. InChI: InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2. InChIKey: JOPCJJSYRPUEDS-UHFFFAOYSA-N. SMILES: O=C1N(CC2=NC3=C(N2CCCC(F)(F)F)C=CC(CN)=C3)C4=CC(F)=CC=C4C15CC5