Sinomenine hydrochloride

Sinomenine is an alkaloid isolated from the Chinese medicinal plant Sinomenium acutum. It has immunomodulating and anti-inflammatory activities. Its anti-arthritic propery is related to the antiproliferative effects on synovial fibroblasts and lymphocytes. Other antirheumatic mechanisms are attributed to its ability to decrease PGE2 and leukotriene C4 synthesis, and inhibit NO production. It also prevents myocardial injury by lowering intracellular Ca2 accumulation.