SH5-07

SH5-07 is a STAT3 inhibitor (Ki = 10.46 µM). It is selective for STAT3 over STAT1 (Ki = >100 µM). SH5-07 prevents constitutively active STAT3 DNA binding in NIH3T3 fibroblast nuclear extracts (IC50 = 3.9 µM). It is cytotoxic to AR230 and imatinib-resistant AR230 chronic myeloid leukemia (CML) cells (IC50s = 8.1 and 7 µM, respectively) and a variety of glioblastoma cancer stem cells (CSCs, IC50s = 0.195-1.12 µM). SH5-07 reduces tumor growth in MDA-MB-231 breast cancer and U-251MG glioblastoma mouse xenograft models when administered at doses of 3 and 5 mg/kg, respectively. It is also active against T. gondii when used at a concentration of 5 µM.Formal Name: 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-benzamide. CAS Number: 1456632-41-9. Molecular Formula: C29H28F5N3O5S. Formula Weight: 625.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/mL, DMSO: 3 mg/mL, Ethanol: 3 mg/mL. SMILES: O=C(C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)C)=O)C=C1)NO. InChi Code: InChI=1S/C29H28F5N3O5S/c1-36(43(41,42)28-26(33)24(31)23(30)25(32)27(28)34)16-22(38)37(21-13-11-20(12-14-21)29(39)35-40)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18,40H,2-6,15-16H2,1H3,(H,35,39). InChi Key: QPSUYVALAOXFGL-UHFFFAOYSA-N.