Zu "K04692" wurden 210 Artikel gefunden!
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NEU
STAT3-IN-12
Artikelnummer: Cay44651-10
STAT3-IN-12 is an inhibitor of STAT3 (IC50 = 2. µM). It induces apoptosis in HepG2 hepatocellular carcinoma and EC109 esophageal carcinoma cells when used at concentrations of 5, 10, and 20 µM. In vivo, STAT3-IN-12 (20 and 40 mg/kg) reduces tumor volume in a HepG2 mouse xenograft model. Formal Name:...
| Schlagworte: | Signal Transducer and Activator of Transcription 3 Inhibitor 12, Signal Transducer and Activator of Transcription 3-IN-12,... |
| Anwendung: | STAT3 inhibitor |
| CAS | 2980758-31-2 |
| MW: | 454.57 D |
ab 79,00 €
Anti-Recombinant Phospho-STAT3 (Ser727), clone 6H7
Artikelnummer: E-AN301146L.100
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This...
| Schlagworte: | Anti-STAT3, Anti-Acute-phase response factor, Anti-Signal transducer and activator of transcription 3, Recombinant... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 258,00 €
Anti-Polycystin 1 / PKD1
Artikelnummer: NSJ-R36500-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Polycystin 1, also known as PKD1, is a protein encoded by the PKD1 gene and is crucial in the development of Polycystic Kidney Disease (PKD). PKD1 mutations are responsible for the majority of cases of autosomal dominant PKD, a genetic...
| Schlagworte: | Anti-STAT3, Anti-Acute-phase response factor, Anti-Signal transducer and activator of transcription 3, Polycystin 1... |
| Anwendung: | IHC (paraffin), ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
Anti-phospho-STAT3 (Ser727), clone CAA-19
Artikelnummer: NSJ-RQ8665
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Stat3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.
| Schlagworte: | Anti-phospho-STAT3, Anti-phospho-Acute-phase response factor, Anti-phospho-Signal transducer and activator of... |
| Anwendung: | WB, IHC (paraffin), IF |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat |
790,00 €
STAT3, GST-tag
Artikelnummer: BPS-75003
Human signal transducer and activator of transcription 3 (STAT3), GenBank Accession No. NM_139276, full length with N-terminal GST-tag, MW=120 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
| Schlagworte: | Acute-phase response factor, Signal transducer and activator of transcription 3, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 120 kD |
774,00 €
STAT3 Reporter Kit (STAT3 Signaling Pathway)
Artikelnummer: BPS-79730
The STAT3 Reporter kit is designed for monitoring the activity of the STAT3 signaling pathway in cultured cells. The kit contains transfection-ready STAT3 luciferase reporter vector. This reporter contains a firefly luciferase gene under the control of STAT3-responsive element located upstream of a minimal promoter....
| Schlagworte: | Acute-Phase Response Factor, APRF, ADMIO1, HIES, |
| Anwendung: | STAT3 pathway activity monitoring, activator / inhibitor screening |
| Spezies-Reaktivität: | human |
1.005,00 €
Anti-Phospho-Stat3 (Tyr705) Monoclonal Recombinant Antibody
Artikelnummer: E-AN300142P.100
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This...
| Schlagworte: | Acute-phase response factor, Signal transducer and activator of transcription 3, Recombinant Phospho-Stat3 (Tyr705)... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 182,00 €
Stattic
Artikelnummer: Cay14590-10
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities. Stattic is a small molecule...
| Schlagworte: | STAT3 Inhibitor V, 6-nitro-1,1-dioxide-benzo[b]thiophene |
| Anwendung: | STAT3 inhibitor |
| CAS | 19983-44-9 |
| MW: | 211.2 D |
ab 85,00 €
STAT3 (human), recombinant protein (GST Tag)
Artikelnummer: E-PDEH100640.1
Protein function: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771,...
| Schlagworte: | Acute-phase response factor, Signal transducer and activator of transcription 3, Recombinant Human STAT3 Protein(GST Tag) |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
ab 192,00 €
Cucurbitacin I
Artikelnummer: Cay14747-1
Cucurbitacin I is triterpenoid compound that acts as a potent inhibitor of the STAT3/JAK signaling pathway. It specifically suppresses levels of tyrosine phosphorylated STAT3 in v-Src-transformed NIH 3T3 cells and in A549 cells (IC50 = 500 nM) resulting in inhibition of STAT3 DNA binding and reduced STAT3-mediated...
| Schlagworte: | Elatericin B, JSI-124, NSC 521777,... |
| Anwendung: | STAT3/JAK signaling pathway inhibitor |
| CAS | 2222-07-3 |
| MW: | 514.7 D |
ab 143,00 €
COVID-19 Forschung
Niclosamide
Artikelnummer: Cay10649-25
Niclosamide is a molluscicide. It is toxic to H. trivolvis snail eggs, juveniles, and adults (LC50s = 0.035, 0.044, and 0.11 mg/kg, respectively), as well as rainbow trout, white sucker, and fathead minnow (LC50s = 0.03, 0.09, and 0.11 mg/L, respectively). Niclosamide induces cell cycle arrest at the G0/G1 phase and...
| Schlagworte: | NSC 178296, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide |
| Anwendung: | STAT3 inhibitor |
| CAS | 50-65-7 |
| MW: | 327.1 D |
73,00 €
W1131
Artikelnummer: Cay42902-1
W1131 is a STAT3 inhibitor. It selectively inhibits the phosphorylation of STAT3 over STAT1, STAT5, JAK2, and Akt in AGS gastric adenocarcinoma cells at 3 µM. W1131 binds to STAT3 in a cell-free assay (Kd = 7. µM) and increases the thermal stability of STAT3 in a cellular thermal shift assay (CETSA) using AGS cells...
| Schlagworte: | 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl]-2-furancarboxamide |
| Anwendung: | STAT3 inhibitor |
| CAS | 2740522-79-4 |
| MW: | 429.44 D |
ab 103,00 €