Zu "K04692" wurden 205 Artikel gefunden!
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inS3-54-A18
Artikelnummer: Cay39678-1
inS3-54-A18 is an inhibitor of STAT3. It selectively inhibits the binding of STAT3 to DNA over STAT1 at 25 µM. inS3-54-A18 (20 µM) inhibits STAT3 activity in a reporter assay using MDA-MB-231 breast cancer cells. It induces apoptosis in, and reduces migration and invasion of, A549 non-small cell lung cancer (NSCLC)...
| Schlagworte: | 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-2H-pyrrol-2-one |
| Anwendung: | STAT3 inhibitor |
| CAS | 328998-53-4 |
| MW: | 373.8 D |
ab 66,00 €
Human STAT3 (Signal Transducer And Activator Of...
Artikelnummer: ELK-ELK5550.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human STAT3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human STAT3. Next,...
| Schlagworte: | Acute-phase response factor, Signal transducer and activator of transcription 3 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Human STAT3 (Signal Transducer And Activator Of...
Artikelnummer: ELK-ELK5142.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human STAT3. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human STAT3. Next,...
| Schlagworte: | Acute-phase response factor, Signal transducer and activator of transcription 3 |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 303,00 €
Anti-STAT3
Artikelnummer: ELK-EA234.100
Signal transducer and activator of transcription 3, also known as STAT3, is a transcription factor which in humans is encoded by the STAT3 gene. Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Protein function: Signal transducer and...
| Schlagworte: | Anti-Acute-phase response factor, Anti-Signal transducer and activator of transcription 3, STAT3 Rabbit pAb |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
283,00 €
STAT3, GST-tag
Artikelnummer: BPS-75003
Human signal transducer and activator of transcription 3 (STAT3), GenBank Accession No. NM_139276, full length with N-terminal GST-tag, MW=120 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
| Schlagworte: | Acute-phase response factor, Signal transducer and activator of transcription 3, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 120 kD |
706,00 €
STAT3 Reporter Kit (STAT3 Signaling Pathway)
Artikelnummer: BPS-79730
The STAT3 Reporter kit is designed for monitoring the activity of the STAT3 signaling pathway in cultured cells. The kit contains transfection-ready STAT3 luciferase reporter vector. This reporter contains a firefly luciferase gene under the control of STAT3-responsive element located upstream of a minimal promoter....
| Schlagworte: | Acute-Phase Response Factor, APRF, ADMIO1, HIES, |
| Anwendung: | STAT3 pathway activity monitoring, activator / inhibitor screening |
| Spezies-Reaktivität: | human |
941,00 €
Stattic
Artikelnummer: Cay14590-10
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities. Stattic is a small molecule...
| Schlagworte: | STAT3 Inhibitor V, 6-nitro-1,1-dioxide-benzo[b]thiophene |
| Anwendung: | STAT3 inhibitor |
| CAS | 19983-44-9 |
| MW: | 211.2 D |
ab 77,00 €
SH5-07
Artikelnummer: Cay36818-10
SH5-07 is a STAT3 inhibitor (Ki = 10.46 µM). It is selective for STAT3 over STAT1 (Ki = >100 µM). SH5-07 prevents constitutively active STAT3 DNA binding in NIH3T3 fibroblast nuclear extracts (IC50 = 3.9 µM). It is cytotoxic to AR230 and imatinib-resistant AR230 chronic myeloid leukemia (CML) cells (IC50s = 8.1 and...
| Schlagworte: | 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-benzamide |
| Anwendung: | STAT3 inhibitor |
| CAS | 1456632-41-9 |
| MW: | 625.6 D |
ab 340,00 €
Cucurbitacin I
Artikelnummer: Cay14747-1
Cucurbitacin I is triterpenoid compound that acts as a potent inhibitor of the STAT3/JAK signaling pathway. It specifically suppresses levels of tyrosine phosphorylated STAT3 in v-Src-transformed NIH 3T3 cells and in A549 cells (IC50 = 500 nM) resulting in inhibition of STAT3 DNA binding and reduced STAT3-mediated...
| Schlagworte: | Elatericin B, JSI-124, NSC 521777,... |
| Anwendung: | STAT3/JAK signaling pathway inhibitor |
| CAS | 2222-07-3 |
| MW: | 514.7 D |
ab 129,00 €
COVID-19 Forschung
Niclosamide
Artikelnummer: Cay10649-25
Niclosamide is a molluscicide. It is toxic to H. trivolvis snail eggs, juveniles, and adults (LC50s = 0.035, 0.044, and 0.11 mg/kg, respectively), as well as rainbow trout, white sucker, and fathead minnow (LC50s = 0.03, 0.09, and 0.11 mg/L, respectively). Niclosamide induces cell cycle arrest at the G0/G1 phase and...
| Schlagworte: | NSC 178296, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide |
| Anwendung: | STAT3 inhibitor |
| CAS | 50-65-7 |
| MW: | 327.1 D |
66,00 €
Anti-STAT3 (recombinant antibody), clone RM465
Artikelnummer: NSJ-R20477-0.1ML
Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This antibody reacts to human Stat3. Protein function: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986,...
| Schlagworte: | Anti-Acute-phase response factor, Anti-Signal transducer and activator of transcription 3, Recombinant STAT3 Antibody |
| Anwendung: | WB, IHC (paraffin) |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
737,00 €
5,15-DPP
Artikelnummer: Cay16090-10
Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. 5,15-DPP is a cell-permeable porphyrin derivative that selectively binds STAT3 (Kd = 880 nM). This inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 = 280...
| Schlagworte: | 5,15-Diphenylporphyrin, STAT3 Inhibitor VIII, 5,15-diphenyl-21H,23H-porphine |
| Anwendung: | STAT3 dimerization inhibitor |
| CAS | 22112-89-6 |
| MW: | 462.6 D |
ab 43,00 €