SEN-12333

SEN-12333 is an agonist of alpha7 nicotinic acetylcholine receptors (nAChRs, Ki = 0.26 µM). It is selective for alpha7 nAChRs over alpha1-, alpha3-, and alpha4beta2 subunit-containing nAChRs and the serotonin (5-HT) receptor subtype 5-HT3, as well as a panel of 70 additional neurotransmitter, growth factor, and peptide receptors at 10 µM. SEN-12333 activates the alpha7 nAChR in GH4C1 cells expressing the rat receptor (EC50 = 1.6 µM). Topical application of SEN-12333 prevents decreases in the number of retinal ganglion cells in a rat model of glaucoma in a concentration-dependent manner. SEN-12333 (3 mg/kg) reverses scopolamine- or MK-801-induced memory deficits in the novel object recognition test in rats.Formal Name: N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide. CAS Number: 874450-44-9. Synonyms: WAY-317538. Molecular Formula: C20H25N3O2. Formula Weight: 339.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): insol. lambdamax: 282 nm. SMILES: O=C(CCCCN1CCOCC1)NC2=CC=C(C3=CN=CC=C3)C=C2. InChi Code: InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24). InChi Key: XCHIZTUBUXZESJ-UHFFFAOYSA-N.