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A plasma kallikrein inhibitor (IC50 = 6 nM), selective for plasma kallikrein over a panel of 14 additional proteases (IC50s = >10 µM for all), inhibits dextran sulfate-induced cleavage of kininogen-1 in isolated human plasma from 50-1,000 nM. SMILES: O=C1C=CC=CN1CC2=CC=C(CN3N=C(COC)C(C(NCC4=NC=CC(OC)=C4F)=O)=C3)C=C2. InChi Code: InChI=1S/C26H26FN5O4/c1-35-17-22-20(26(34)29-13-21-25(27)23(36-2)10-11-28-21)16-32(30-22)15-19-8-6-18(7-9-19)14-31-12-4-3-5-24(31)33/h3-12,16H,13-15,17H2,1-2H3,(H,29,34). InChi Key: KGMPDQIYDKKXRD-UHFFFAOYSA-N