Scopine (hydrochloride)

Scopine is an active metabolite of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine (Cay-40307). Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM). It reduces hyperphagia induced by the antipsychotics loxapine (Cay-20760) and chlorpromazine (Cay-16129) in C. elegans without affecting basal feeding. When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil (Cay-23744).Formal Name: (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol, monohydrochloride. CAS Number: 85700-55-6. Molecular Formula: C8H13NO2 . HCl. Formula Weight: 191.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 5 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 203 nm. SMILES: O[C@H]1C[C@H](N2C)[C@@H]3O[C@@H]3[C@H]2C1.Cl. InChi Code: InChI=1S/C8H13NO2.ClH/c1-9-5-2-4(10)3-6(9)8-7(5)11-8,/h4-8,10H,2-3H2,1H3,1H/t4-,5-,6+,7-,8+,. InChi Key: BBBRAOXIMQHVCR-YSJWXMLMSA-N.