SCH 79797 (hydrochloride)

SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1). It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or alpha-thrombin (IC50 = 0.3 and 3 µM, respectively). SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation. It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells.Formal Name: N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine, monohydrochloride. CAS Number: 1216720-69-2. Molecular Formula: C23H25N5 . 2HCl. Formula Weight: 444.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 11 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 1 mg/ml. lambdamax: 214, 246, 340 nm. SMILES: NC1=NC(NC2CC2)=NC3=CC=C(N(CC4=CC=C(C(C)C)C=C4)C=C5)C5=C31.Cl.Cl. InChi Code: InChI=1S/C23H25N5.2ClH/c1-14(2)16-5-3-15(4-6-16)13-28-12-11-18-20(28)10-9-19-21(18)22(24)27-23(26-19)25-17-7-8-17,,/h3-6,9-12,14,17H,7-8,13H2,1-2H3,(H3,24,25,26,27),2*1H. InChi Key: NNJTXSQXGHYXAJ-UHFFFAOYSA-N.