SC-75741

SC-75741 is an inhibitor of NF-kappaB (EC50 = 0.2 µM in an NF-kappaB reporter gene assay). It inhibits replication of human, avian, and swine influenza virus strains in MDCK cells in a concentration-dependent manner. It also reversibly inhibits replication of H5N1 and H7N7 avian influenza virus strains in human A549 cells. In vivo, SC-75741 (15 mg/kg, i.p.) reduces viral mRNA and production of IL-6 and CXCL10/IP-10 in the lungs of H5N1 infected mice. SC-75741 is also protective against H5N1 and H7N7 infection in mice when administered for 7 days prior to or up to 4 days post infection.Formal Name: N-(6-benzoyl-1H-benzimidazol-2-yl)-2-(1-thieno[3,2-d]pyrimidin-4-yl-4-piperidinyl)-4-thiazolecarboxamide. CAS Number: 913822-46-5. Molecular Formula: C29H23N7O2S2. Formula Weight: 565.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.2 mg/ml, DMSO: 0.5 mg/ml, DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml. lambdamax: 206, 256, 313 nm. SMILES: O=C(NC1=NC(C=CC(C(C2=CC=CC=C2)=O)=C3)=C3N1)C4=CSC(C5CCN(C6=C7C(C=CS7)=NC=N6)CC5)=N4. InChi Code: InChI=1S/C29H23N7O2S2/c37-24(17-4-2-1-3-5-17)19-6-7-20-22(14-19)34-29(33-20)35-27(38)23-15-40-28(32-23)18-8-11-36(12-9-18)26-25-21(10-13-39-25)30-16-31-26/h1-7,10,13-16,18H,8-9,11-12H2,(H2,33,34,35,38). InChi Key: QNZVBFMXWNWVKG-UHFFFAOYSA-N.