sbp-7455

Description: SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice. Target: Autophagy. Smiles: COc1ccc(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cc1OC. References: Ren H, Bakas NA, Vamos M, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020,63(23):14609-14625. doi:10.1021/acs.jmedchem.0c00873