SB-756050

SB-756050 is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50 = 1.3 µM for the human receptor). It is selective for TGR5 over the farnesoid X receptor (FXR) and a panel of other receptors, channels, and transporters. SB-756050 (10-100 mg/kg) decreases fasting glucose levels and increases glucose disposal rate and insulin secretion in diabetic Goto Kakizaki rats.Formal Name: 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]hexahydro-1H-1,4-diazepine. CAS Number: 447410-57-3. Molecular Formula: C21H28N2O8S2. Formula Weight: 500.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.25 mg/ml, DMSO: 10 mg/ml. lambdamax: 249, 283 nm. SMILES: COC1=CC=C(S(N2CCCN(S(C3=CC=C(OC)C(OC)=C3)(=O)=O)CC2)(=O)=O)C=C1OC. InChi Code: InChI=1S/C21H28N2O8S2/c1-28-18-8-6-16(14-20(18)30-3)32(24,25)22-10-5-11-23(13-12-22)33(26,27)17-7-9-19(29-2)21(15-17)31-4/h6-9,14-15H,5,10-13H2,1-4H3. InChi Key: GJUFPAZNBPFNRI-UHFFFAOYSA-N.