Zu "K08400" wurden 49 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
CHO-K1/GPBAR1 Stable Cell Line
Artikelnummer: GSC-M00432
The gene GPBRA1 encodes G protein-coupled bile acid receptor. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production.
| Schlagworte: | hBG37, GPBAR1, G-protein coupled receptor GPCR19, Membrane-type receptor for bile acids, G-protein coupled bile acid... |
11.424,00 €
INT-777
Artikelnummer: Cay17678-500
TGR5 is a transmembrane G protein-coupled receptor that is activated by bile acid. INT-777 is a semisynthetic bile acid that acts as an agonist of TGR5 (EC50 = 0.82 µM). It is active in vivo, stimulating the secretion of glucagon-like peptide 1 (GLP-1) in mice when given orally (30 mg/kg) after a glucose challenge,...
| Schlagworte: | HY-15677, 6-EMCA, S-EMCA, (3alpha,5beta,6alpha,7alpha,12alpha,23S)-6-ethyl-3,7,12-trihydroxy-cholane-23-carboxylic acid |
| Anwendung: | TGR5 agonist |
| CAS | 1199796-29-6 |
| MW: | 450.7 D |
ab 181,00 €
Dehydrolithocholic Acid
Artikelnummer: Cay29544-10
Dehydrolithocholic acid is a major metabolite of lithocholic acid (LCA, Cay-20253). It is formed from LCA by the cytochrome P450 (CYP) isoform CYP3A4. Dehydrolithocholic acid is an agonist of G protein-coupled bile acid activated receptor 1 (GP-BAR1/TGR5, EC50 = 0.27 µM), vitamin D receptor (VDR, EC50 = 3 µM), and...
| Schlagworte: | 3-Ketolithocholic Acid, 3-oxo Lithocholic Acid, 3-oxoLCA, (5beta)-3-oxo-cholan-24-oic acid |
| Anwendung: | Major lithocholic acid metabolite, TGR5 / VDR / FXR agonist |
| CAS | 1553-56-6 |
| MW: | 374.6 D |
ab 49,00 €
5beta-Cholestane-3alpha,7alpha,12alpha,25-tetrol
Artikelnummer: Cay42577-1
5beta-Cholestane-3alpha,7alpha,12alpha,25-tetrol is a bile acid alcohol. It induces activation of G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5, in HEK293 cells expressing the human receptor when used at concentrations ranging from 0. to 10 µM. Blood, fecal, and bile levels of...
| Schlagworte: | 3alpha,7alpha,12alpha,25-Tetrahydroxycoprostane |
| Anwendung: | Bile acid alcohol, GPBAR1 (TGR5) agonist |
| CAS | 18866-87-0 |
| MW: | 436.67 D |
ab 83,00 €
TGR5 Receptor Agonist
Artikelnummer: Cay16291-1
TGR5 receptor agonist is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays). It stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM). TGR5 receptor agonist (1 mg/kg) increases glucagon-like peptide 1 (GLP-1) secretion and decreases glucose...
| Schlagworte: | 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide |
| Anwendung: | GPBAR1 agonist |
| CAS | 1197300-24-5 |
| MW: | 361.2 D |
ab 49,00 €
Betulinic Acid
Artikelnummer: Cay11686-50
Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol. Betulinic...
| Schlagworte: | Lupatic Acid, NSC 113090, 3beta-hydroxy-lup-20(29)-en-28-oic acid |
| Anwendung: | TGR5 agonist |
| CAS | 472-15-1 |
| MW: | 456.7 D |
ab 54,00 €
TGR5 (GP-BAR1) Reporter Assay Kit
Artikelnummer: Cay601440-1
Bile acids are a diverse class of amphipathic molecules originally formed in liver and modified by microorganisms in the intestine. In addition to their conventional role in dietary lipid absorption, bile acids have been recognized as signaling molecules that regulate the synthesis and metabolism of bile acids,...
| Schlagworte: | BG37, TGR5, M-BAR, hBG37, GPBAR1, hGPCR19, G-protein coupled receptor GPCR19, Membrane-type receptor for bile acids,... |
| Anwendung: | Cell based assays, HTS, reverse transfection reporter assay |
689,00 €
BAR501
Artikelnummer: Cay22460-1
BAR501 is a selective agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1, EC50 = 1 µM) that lacks activity at the farnesoid X receptor (FXR). In vivo, BAR501 reduces hepatic perfusion pressure and counteracts norepinephrine-induced vasoconstriction in naïve rats. It protects against development...
| Schlagworte: | (3alpha,5beta,6beta,7beta)-6-ethyl-cholane-3,7,24-triol |
| Anwendung: | Selective GPBAR1 agonist |
| CAS | 1632118-69-4 |
| MW: | 406.6 D |
ab 56,00 €
TGR5 Receptor Agonist
Artikelnummer: LKT-T2668.1
TGR5 agonist.
| Schlagworte: | TGR5 |
| Anwendung: | TGR5 agonist |
| CAS | 1197300-24-5 |
| MW: | 361.22 D |
ab 157,00 €
SBI-115
Artikelnummer: Cay39168-10
SBI-115 is an antagonist of G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5. It inhibits taurolithocholic acid-induced increases in cAMP levels in, and proliferation of, cholangiocytes isolated from patients with autosomal dominant polycystic kidney disease when used at concentrations of 100 and...
| Schlagworte: | 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylic acid 3-methylphenyl ester |
| Anwendung: | GPBAR1 antagonist |
| CAS | 882366-16-7 |
| MW: | 340.8 D |
ab 83,00 €
Anti-BG37
Artikelnummer: 100-401-H59
Anti-BG37 Antibody is sera. A BLAST analysis was used to suggest cross-reactivity with BG37 from human and mouse based on 100% homology with the immunizing sequence. Predicted reactivity with cow. Cross-reactivity with BG37 from other sources has not been determined. Protein function: Receptor for bile acid. Bile...
| Schlagworte: | Anti-TGR5, Anti-BG37, Anti-M-BAR, Anti-hBG37, Anti-GPBAR1, Anti-hGPCR19, Anti-G-protein coupled receptor GPCR19,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
960,00 €
BAR502
Artikelnummer: Cay22462-1
BAR502 is a dual agonist of the G protein-coupled bile acid-activated receptor and farnesoid x receptor (GP-BAR1 and FXR, EC50s = 0.2 and 1 µM, respectively). It increases the expression of the FXR-regulated bile salt export pump (BSEP), organic solute transporter alpha (OSTalpha), and small heterodimer partner...
| Schlagworte: | (3alpha,5beta,6alpha,7alpha)-6-ethyl-24-norcholane-3,7,23-triol |
| Anwendung: | GPBAR1 /FXR dual agonist |
| CAS | 1612191-86-2 |
| MW: | 392.6 D |
ab 50,00 €