SB-334867

SB-334867 is an antagonist of the orexin 1 receptor (OX1R, KB = 39.8 nM) that is selective for OX1R over OX2R (KB = 1,995.3 nM). It reduces food intake and increases resting duration in rats, as well as inhibits orexin-A-induced increases in food intake, when administered at a dose of 30 mg/kg. SB-334867 (10 mg/kg) inhibits orexin-A-induced increases in grooming time in rats. It increases the seizure threshold in both the maximal electroshock seizure threshold (MEST) and 6 Hz psychomotor seizure test in mice when administered at doses of 30 and 3 mg/kg, respectively. Intracerebroventricular administration of SB-334867 (0.5-50 nmol) reduces morphine-induced analgesia in the formalin test in rats. SB-334867 (1.5 to 6 µg, intra-dentate gyrus injection) also reduces acquisition and consolidation of spatial memory in the Morris water maze in rats.Formal Name: N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-urea. CAS Number: 792173-99-0. Molecular Formula: C17H13N5O2. Formula Weight: 319.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Ethanol: 10 mM. lambdamax: 242, 316 nm. SMILES: O=C(NC1=CC=C(N=C(C)O2)C2=C1)NC3=C4C(C=CC=N4)=NC=C3. InChi Code: InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23). InChi Key: AKMNUCBQGHFICM-UHFFFAOYSA-N.