Zu "K04238" wurden 50 Artikel gefunden!
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CHO-K1/OX1 Stable Cell Line
Artikelnummer: GSC-M00224
Recombinant CHO-K1 cells stably overexpress human hypocretin receptor 1 (OX1) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.
| Schlagworte: | HCRTR1, Orexin receptor type 1, Hypocretin receptor type 1, Orexin/Hypocretin receptor type 1 |
11.424,00 €
Anti-OX1R and OX2R, Internal
Artikelnummer: ARG64584.100
Protein function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade. [The UniProt Consortium]
| Schlagworte: | Anti-Ox1R, Anti-Ox1-R, Anti-Ox-1-R, Anti-HCRTR1, Anti-Orexin receptor type 1, Anti-Hypocretin receptor type 1 |
| Anwendung: | ELISA, WB |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse, rat |
871,00 €
Human OX1R (Orexin receptor type 1) ELISA Kit
Artikelnummer: G-HUFI00849.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
698,00 €
Anti-Orexin receptor
Artikelnummer: NSJ-R35702-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Hypocretin receptor-1, HCRTR1 Protein function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to...
| Schlagworte: | Anti-Ox1R, Anti-Ox1-R, Anti-Ox-1-R, Anti-HCRTR1, Anti-Orexin receptor type 1, Anti-Hypocretin receptor type 1, Orexin... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human |
836,00 €
Anti-Orexin receptor 1
Artikelnummer: NSJ-R36388-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Hypocretin (orexin) receptor 1, HCRTR1 Protein function: Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively...
| Schlagworte: | Anti-Ox1R, Anti-Ox1-R, Anti-Ox-1-R, Anti-HCRTR1, Anti-Orexin receptor type 1, Anti-Hypocretin receptor type 1, Orexin... |
| Anwendung: | WB, ELISA (peptide) |
| Wirt: | Goat |
| Spezies-Reaktivität: | human, mouse, rat |
836,00 €
Almorexant (hydrochloride)
Artikelnummer: Cay13638-1
Almorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 4.7 and 0.9 nM, respectively, in a radioligand binding assay). It decreases the latency to persistent non-rapid eye movement (NREM) sleep and increases the duration of NREM and REM sleep in male rats when administered at a dose of 100 mg/kg....
| Schlagworte: | ACT 078573,... |
| Anwendung: | HCRTR1/2 antagonist |
| CAS | 913358-93-7 |
| MW: | 549 D |
ab 67,00 €
TCS 1102
Artikelnummer: Cay18495-1
Orexin receptors 1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCS 1102 is a dual antagonist of both OX1R and OX2R (Kis = 0.2 and 3 nM, respectively). It is a poor substrate for P-glycoprotein and, as a result, demonstrates good brain penetration when administered...
| Schlagworte: | (2S)-N-[1,1'-biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide |
| Anwendung: | OX1R / OX2R antagonist |
| CAS | 916141-36-1 |
| MW: | 470.6 D |
ab 49,00 €
Anti-HCRTR1
Artikelnummer: E-AB-12828.120
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. Protein function: Moderately...
| Schlagworte: | Anti-Ox1R, Anti-Ox1-R, Anti-HCRTR1, Anti-Ox-1-R, Anti-Orexin receptor type 1, Anti-Hypocretin receptor type 1, HCRTR1... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
Anti-HCRTR1
Artikelnummer: E-AB-16019.120
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. Protein function: Moderately...
| Schlagworte: | Anti-Ox1R, Anti-Ox1-R, Anti-HCRTR1, Anti-Ox-1-R, Anti-Orexin receptor type 1, Anti-Hypocretin receptor type 1, HCRTR1... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 89,00 €
SB-334867
Artikelnummer: Cay19145-1
SB-334867 is an antagonist of the orexin 1 receptor (OX1R, KB = 39.8 nM) that is selective for OX1R over OX2R (KB = 1,995.3 nM). It reduces food intake and increases resting duration in rats, as well as inhibits orexin-A-induced increases in food intake, when administered at a dose of 30 mg/kg. SB-334867 (10 mg/kg)...
| Schlagworte: | N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-urea |
| Anwendung: | OX1 receptor antagonist |
| CAS | 792173-99-0 |
| MW: | 319.3 D |
ab 38,00 €
SB-674042
Artikelnummer: Cay21270-1
SB-674042 is a potent and selective non-peptide orexin 1 receptor (OX1R) antagonist (Kd = 5.03 and 3.76 nM in whole cell binding and membrane-based assays, respectively). In calcium mobilization studies, it was >100-fold selective for OX1 over OX2 and did not show significant affinity for serotonergic, dopaminergic,...
| Schlagworte: | [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-methanone |
| Anwendung: | OX1 receptor antagonist |
| CAS | 483313-22-0 |
| MW: | 448.5 D |
ab 52,00 €
SB-408124
Artikelnummer: Cay22961-10
SB-408124 is a potent antagonist of orexin 1 receptors (OX1Rs) with a Ki value of 26.9 nM in a calcium mobilization assay using CHO cells that stably express human OX1R. It is selective for OX1R over OX2R, with Kd values of 21.7 and 1,704 nM, respectively, in a radioligand binding assay. In vivo co-perfusion of...
| Schlagworte: | N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-urea |
| Anwendung: | OX1R antagonist |
| CAS | 288150-92-5 |
| MW: | 356.4 D |
ab 122,00 €