Salvinorin A Carbamate

Description: Salvinorin A carbamate, a potent kappa-opioid receptor (KOR) full agonist, exhibits nearly the same potency as salvinorin A, with EC50 values of 6.2 and 4.5 nM, respectively, for activating the human KOR to augment the binding of [35S]GTPgammaS. Enhancing biological stability, the addition of a carbamate group to salvinorin A reduces deacetylation. Target: Others. Smiles: COC(=O)[C@@H]1C[C@H](OC(N)=O)C(=O)[C@H]2[C@@]1(C)CC[C@H]1C(=O)O[C@@H](C[C@]21C)c1ccoc1